Geographically, USSIA has functioning Offices in 27 Zones that are d located in 25 Political Districts. These are located in the following Towns:
Luweero, Masaka, Mukono, Kaliro, Kamuli, Busia, Bugiri, Iganga, Jinja, Kasese, Kabale, Kayunga, Rakai, Masindi, Mbale, Mbarara, Mityana, Lugazi, Ntungamo, Mpigi, Kasangati, Kalangala, Mubende, Rukungiri, Kabalore, Kajjansi and Kampala West.
In the past USSIA used to cover the Northern region, but of now, a sister organization Northern Uganda Manufacturers Association (NUMA) currently covers the former USSIA Zones of the North, North-Eastern, North- West and West Nile in the districts of Soroti, Gulu, Lira, Nebbi, Arua and Moyo. NUMA works closely with USSIA as partner in a number of Projects that have proved successful and promoting the performance of the industrialists at the grass root level.
In 2013 USSIA used the regional approach in bringing its services closer to its members. Through the regional approach, USSIA has been able to set up regional offices in Kampala, Mabara, Gulu, Jinja, Kabarole and Hoima with the help of its partners.